THE EFFECTS OF DEXTRM SULFATE, HEPARIN ;tL’D PGEl ON ADENYLATE CYCLASE ACTIYITY AND AGGREGATION OF HUMA.. PLATELETS
نویسندگان
چکیده
ABSTFACT Prostaglandin E (PGE1) sensitive adenylate cyclase rEC.4.6.1.1 ATP-pyrophosphaie lyase (cyclizing)] in human platelet lysates is inhibited by dextran sulfate. Inhibition is dose-dependent at the range of l-10 ug/ml. Maximal inhibition obtained was 85% at 30 ug/ml . At a similar range of concentrations dextran sulfate was found to antagonize the anti-aggregating effect of PGEl on adenosins 5’ diphosphate (ADP) induced human platelet aggregation. Heparin, like dextran sulfate, effectively antagonizes the anti-aggregating effect of PGEl in human platelets. It is possible that the aggregating effects of both heparin and dextran sulfate on human platelets may be mediated via inhibition of platelet PGEl-sensitive adenylate cyclase.
منابع مشابه
Ascorbate Free Human Lens
the soluble friction of the leps protein. AFR reductase actiyity in either irnmatur'e senile cataractous or transp'aTent lens wis higher in the cortex, wheTe the level of insoluble protein is lower, than in the nucleus. The high reductase activitT and low insoluble protein content of the cortex' were coniparable between the assayed cataracr tous and transparent lenses, Iri the nucleusi in contF...
متن کاملGains from diversification on convex combinations: A majorization and stochastic dominance approach
By incorporating both majorization theory and stochastic dominance theory, this paper presents a general theory and a unifying framework for determining the diversification preferences of risk-averse investors and conditions under which they would unanimously judge a particular asset to be superior. In particular, we develop a theory for comparing the preferences of different convex combination...
متن کاملImproved immunogenicity of tetanus toxoid by Brucella abortus S19 LPS adjuvant.
BACKGROUND Adjuvants are used to increase the immunogenicity of new generation vaccines, especially those based on recombinant proteins. Despite immunostimulatory properties, the use of bacterial lipopolysaccharide (LPS) as an adjuvant has been hampered due to its toxicity and pyrogenicity. Brucella abortus LPS is less toxic and has no pyrogenic properties compared to LPS from other gram negati...
متن کاملSteady electrodiffusion in hydrogel-colloid composites: macroscale properties from microscale electrokinetics.
A rigorous microscale electrokinetic model for hydrogel-colloid composites is adopted to compute macroscale profiles of electrolyte concentration, electrostatic potential, and hydrostatic pressure across membranes that separate electrolytes with different concentrations. The membranes are uncharged polymeric hydrogels in which charged spherical colloidal particles are immobilized and randomly d...
متن کاملPerturbative Analysis of Dynamical Localisation
In this paper we extend previous results on convergent perturbative solutions of the Schrödinger equation of a class of periodically timedependent two-level systems. The situation treated here is particularly suited for the investigation of two-level systems exhibiting the phenomenon of (approximate) dynamical localisation. We also present a convergent perturbative expansion for the secular fre...
متن کامل